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Sleeping Person Long Covid

Berberine, Taurine, Nattokinase
and Essential Minerals
for
Long Covid

Protocol Summary

With the help of Essential Minerals, Berberine and Taurine mitigate altered findings common to patients with Long Covid. Nattokinase degrades SARS-Cov-2 proteins throughout the body and clears inflammatory debris from far reaches of the circulatory system. Samples of these protocols are available for viewing below(I do not sell these protocols).

Sample Protocols:

Severe

Maintenance

Long Covid Summary

In Long Covid, viral persistence, novel autoimmunity, reactivated viruses, and/or immune cell exhaustion push the body into a debilitating and sometimes progressive state of chronic illness. The body assumes the worst and produces fast fuel from pyruvate and lactic acid for exhausted immune cells. Prolonged amino gluconeogenesis desensitizes metabolic pathways to glucose and/or insulin and feeds unwanted bacteria, neoplasms, and mycoflora in the process. CD8+ T cell exhaustion, peripheral blood mononuclear cell dysfunction, and fungal translocation lead to a wide array of debilitating patient-specific symptoms.
More information below.

Cautions and Contraindications

Do not take Berberine or Taurine without talking to your doctors first(especially if you are already taking medications). Large amounts of Berberine can slow the metabolism and clearance of certain medications metabolized by the liver. Though plasma Taurine is often deficient in patients with Long Covid and ME, plasma Taurine may be elevated in those with elevated liver enzymes and/or Systemic Lupus Erythmatosus(SLE) in which case supplemental Taurine should only be taken at smaller doses.

Berberine and COVID-19 are two of the most heavily researched subjects in medicine.

Protocol Mechanisms of Action:

A wide array of Essential Minerals are the building blocks, the fuel, and the first line of defense from oxidative stress in the mitochondria. Supplemental Taurine can enhance the protective and sustaining effect of Essential Minerals within the mitochondria, upregulate antioxidants like glutathione, strengthen organelle and cell membranes, optimize intestinal pH for healthy bacteria, and refold degraded proteins in the brain to prevent prion formation.

Berberine and Taurine can cool down amino hepatic gluconeogenesis by inhibiting lactic acidosis, improving lipid/glucose metabolism, protecting metabolic tissue from oxidative stress, stabilizing mast cell degranulization, activating AMPK, and increasing ATP output at the cellular level by at least 20%. Berberine and Taurine inhibit inflammatory responses to particle reservoirs, reactivated HSV, and reactivated EBV reducing excess fibronectin to prevent stubborn clotting. Berberine is potently antimicrobial against disease causing bacteria, fungi, yeast, and SARS-Cov-2. Berberine and Taurine redistribute minerals to reduce inflammation and remineralize bone. Berberine and Taurine strengthen tight junctions in the intestines and reduce inflammation to restore intestinal lining integrity.

Protocols also include Nattokinase to degrade and dislodge persistent spike, Binders to absorb viral particulate and mycotoxins in the gut, and probiotics to maintain a defensive biome.

Female hero doctor with mask and face shield crying tear due to coronavirus covid-19 situa...ted.jpg

Concerns and Hopes​

Cures, in a broad sense, do not exist nor are they what marketing companies claim them to be. "Cures" enable aspects of capitalist and eugenic culture designed to make money only to leave others behind as seen in the global response to COVID-19.

More and more research is warning of progressive neurodegenerative disease after COVID-19. If you haven't already, consider applying for disability subsidies in your country if you qualify and/or if your ability to provide for yourself has changed or become unpredictable because of COVID-19.

Berberine and Taurine
COVID-19 Flow Chart(5).png

Metabolic / Mitochondrial / Redox Imbalance:


↓taurine

↓glutamine/glutamate ratio

↓sarcosine


↓arginine, ↑ornithine/citrulline ratio

(↑ammonia, ↑lactate, ↓NO)

 

↑lactate/pyruvate ratio

(Redox State Imbalance, ↓NAD+)

 

↑glucose, ↑lactic acid

(Warburg Effect)

 

↑amino/hepatic gluconeogenisis

(glucose resistance, dysregulated glucose-alanine cycle, →muscle breakdown)

Dysbiosis / Opportunistic Infection:

 

 ↑candida ↑mycotoxins ↑disulfovibrio

Chronic Immune Dysregulation:

 

↑ IL-17 ↑ IL-6, impaired Monocytes

All underlined text above links to correlating citations.

*Metabolome findings based on https://www.medrxiv.org/content/10.1101/2023.05.03.23289456v1.full.pdf

Taurine Deficiecy
Glutamine Decrease
Arginine/Ornithine/Citrulline
Lactate Glucose Increase
amino/hepatic gluconeogenisis

López-Hernández, Yamilé, et al. “The Plasma Metabolome of Long COVID-19 Patients Two Years after Infection.” medRxiv, 1 Jan. 2023, www.medrxiv.org/content/10.1101/2023.05.03.23289456v1

Davis, Hannah E., et al. “Long Covid: Major Findings, Mechanisms and Recommendations.” Nature News, 13 Jan. 2023, www.nature.com/articles/s41579-022-00846-2

Babalghith, Ahmad O., et al. “The Role of Berberine in Covid-19: Potential Adjunct Therapy - Inflammopharmacology.” SpringerLink, 2 Oct. 2022, link.springer.com/article/10.1007/s10787-022-01080-1

Schaffer, Stephen, and Ha Won Kim. “Effects and Mechanisms of Taurine as a Therapeutic Agent.” Biomolecules & Therapeutics, 1

May 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5933890/

 

Schaffer, Stephen W., et al. “Differences between Physiological and Pharmacological Actions of Taurine.” Advances in Experimental edicine and Biology, July 2022, link.springer.com/chapter/10.1007/978-3-030-93337-1_30

Seidel, Huebbe, and Rimbach. “Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function.” Molecular Nutrition & Food Research, August 2019, pubmed.ncbi.nlm.nih.gov/30211983/

 

Jong, Sandal, and Schaffer. “The Role of Taurine in Mitochondria Health: More than Just an Antioxidant.” Molecules (Basel, Switzerland), August 2021, pubmed.ncbi.nlm.nih.gov/34443494/

Michalk, Wingenfeld, et al. “The Mechanisms of Taurine Mediated Protection against Cell Damage Induced by Hypoxia and Reoxygenation.” Advances in Experimental Medicine and Biology, pubmed.ncbi.nlm.nih.gov/8915359/. Accessed 21 May 2023.

Anis, and Zaky. "Glutamine and Taurine: No Longer Supplementary Nutrients." Journal of Anaesthesiology, January 2013, www.researchgate.net/publication/343323133_Glutamine_and_taurine_no_longer_supplementary_nutrients

Zhang, Pengcheng, et al. “Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.” OncoTargets and Therapy, 31 Dec. 2019, www.ncbi.nlm.nih.gov/pmc/articles/PMC6978679/

 

Combs, McClurg. “Sarcosine Dehydrogenase.” Sarcosine Dehydrogenase - an Overview | ScienceDirect Topics, The Vitamins(Sixth Edition), 2022, www.sciencedirect.com/topics/nursing-and-health-professions/sarcosine-dehydrogenase

Walter, Fruzsina R., et al. “Blood–Brain Barrier Dysfunction in L-Ornithine Induced Acute Pancreatitis in Rats and the Direct Effect of L-Ornithine on Cultured Brain Endothelial Cells - Fluids and Barriers of the CNS.” BioMed Central, 17 Feb. 2022, fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-022-00308-0

Ou, Xiaofeng, et al. “Cognitive Impairments Induced by Severe Acute Pancreatitis Are Attenuated by Berberine Treatment in Rats.” Molecular Medicine Reports, 1 Sept. 2018, www.spandidos-publications.com/10.3892/mmr.2018.9313

Li, Jie, et al. “Berberine Inhibits the Warburg Effect through Tet3/Mir-145/HK2 Pathways in Ovarian Cancer Cells.” Journal of Cancer, 1 Jan. 2021, www.jcancer.org/v12p0207.htm

Almani, Suhail Ahmed, et al. “Berberine Protects against Metformin-Associated Lactic Acidosis in Induced Diabetes Mellitus.” Iranian Journal of Basic Medical Sciences, May 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5478779/

Aiyun Li a, et al. “Berberine Reduces Pyruvate-Driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1.” EBioMedicine, 6 Aug. 2018, www.sciencedirect.com/science/article/pii/S2352396418302858

Guo, Wei, et al. “Glutamic-Pyruvic Transaminase 1 Facilitates Alternative Fuels for Hepatocellular Carcinoma Growth-a Small Molecule Inhibitor, Berberine.” MDPI, 9 July 2020, www.mdpi.com/2072-6694/12/7/1854

Ishikura, Keisuke, et al. “Effect of Taurine Supplementation on the Alterations in Amino Acid Content in Skeletal Muscle with Exercise in Rat.” Journal of Sports Science & Medicine, 1 June 2011, www.ncbi.nlm.nih.gov/pmc/articles/PMC3761861/

Sun, Runbin, et al. “The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis.” Drug Metabolism & Disposition, 1 Mar. 2021, dmd.aspetjournals.org/content/49/3/276.abstract

Yu, Y., et al. “Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1A Pathway in Skeletal Muscle from Naturally Aging Rats - The Journal of Nutrition, Health & Aging.” SpringerLink, 6 Mar. 2018, link.springer.com/article/10.1007/s12603-018-1015-7

Kosalec, Ivan, et al. “The Spectrum of Berberine Antibacterial and Antifungal Activities.” SpringerLink, 3 Feb. 2022, link.springer.com/chapter/10.1007/978-3-030-83504-0_7

Li, Jiaojiao, Pin Meng, et al. “Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson’s Disease Patients.” Contrast Media & Molecular Imaging, 30 May 2022, www.ncbi.nlm.nih.gov/pmc/articles/PMC9170458

Duszka, Kalina. “Versatile Triad Alliance: Bile Acid, Taurine and Microbiota.” MDPI, 29 July 2022, www.mdpi.com/2073-4409/11/15/2337

Fu, Ni, Wang, Fu, and Hong. “Berberine Suppresses Mast Cell-Mediated Allergic Responses via Regulating Fcɛri-Mediated and MAPK Signaling.” International Immunopharmacology, March 2019, pubmed.ncbi.nlm.nih.gov/30861392/

 

McCarty, Mark F, et al. “Nutraceutical Aid for Allergies - Strategies for down-Regulating Mast Cell Degranulation.” Journal of Asthma and Allergy, 27 Oct. 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8558634/

 

Tanikawa, Kiba, Yu, et al. “Degradative Effect of Nattokinase on Spike Protein of SARS-COV-2.” Molecules (Basel, Switzerland), August 2022, pubmed.ncbi.nlm.nih.gov/36080170/

Bhat, Mujtaba Aamir, et al. “Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases.” Biomolecules, 5 June 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7355587/

Tavaf, Soltanmohammadi, et al. "Berberine promotes immunological outcomes and decreases neuroinflammation in the experimental model of multiple sclerosis through the expansion of Treg and Th2 cells." - Wiley Online Library, January 2023, onlinelibrary.wiley.com/doi/10.1002/iid3.766

Warowicka, Alicja, et al. “Antiviral Activity of Berberine.” Archives of Virology, Sept. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7320912/

Šudomová, Miroslava, et al. “Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers.” Viruses, 28 May 2021, www.ncbi.nlm.nih.gov/pmc/articles/PMC8229678/

Wang, Kening, et al. “Glutamine Supplementation Suppresses Herpes Simplex Virus Reactivation.” The Journal of Clinical Investigation, 30 June 2017, www.ncbi.nlm.nih.gov/pmc/articles/PMC5490748/

Huang, Kaipeng, et al. “Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models.” PLOS ONE, journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0043874

Ciszewski, Lu-Nguyen, Slater, et al. “G-Quadruplex Ligands Mediate Downregulation of DUX4 Expression.” Nucleic Acids Research, pubmed.ncbi.nlm.nih.gov/32182342/

Ma, Shu-Rong, et al. “Berberine Treats Atherosclerosis via a Vitamine-like Effect down-Regulating Choline-TMA-TMAO Production Pathway in Gut Microbiota.” Nature News, 7 July 2022, www.nature.com/articles/s41392-022-01027-6

 

Zheng, Zhihua, et al. “Identification of Berberine as a Potential Therapeutic Strategy for Kidney Clear Cell Carcinoma and COVID-19 Based on Analysis of Large-Scale Datasets.” Frontiers in Immunology, 23 Mar. 2023, www.ncbi.nlm.nih.gov/pmc/articles/PMC10076552/

Gibellini, Lara, et al. “Altered Bioenergetics and Mitochondrial Dysfunction of Monocytes in Patients with Covid-19 Pneumonia.” EMBO Molecular Medicine, 7 Dec. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7645870/

Wang, Zhao, et al. "Effect of Taurine on Leucocyte Function" - European Journal of Pharmacology, June 2009, www.researchgate.net/publication/223078816_Effect_of_taurine_on_leucocyte_function

Yuhan Zhang, et al. “Berberine for Bone Regeneration: Therapeutic Potential and Molecular Mechanisms.” Journal of Ethnopharmacology, 29 May 2021, www.sciencedirect.com/science/article/abs/pii/S0378874121004761#:~:text=Berberine%20promotes%20osteogenesis,mineralization%20to%20promote%20bone%20formation

Zhu, Xiaofei, et al. “The Mitohormetic Response as Part of the Cytoprotection Mechanism of Berberine - Molecular Medicine.” BioMed Central, 23 Jan. 2020, molmed.biomedcentral.com/articles/10.1186/s10020-020-0136-8

Opportunistic Infections
Neurodegeneration
HHV
Immune Dysregulation
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